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apalutamide will decrease the extent or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medications that are CYP3A4 substrates can result in reduced exposure to those medicines.Belzutifan is really a CYP2C19 substrate. Coadmi